Barbara Potempa Selected Research

Gingipain Cysteine Endopeptidases

1/2022	Proteolytic Activity-Independent Activation of the Immune Response by Gingipains from Porphyromonas gingivalis.
1/2020	Proteolysis of Gingival Keratinocyte Cell Surface Proteins by Gingipains Secreted From Porphyromonas gingivalis - Proteomic Insights Into Mechanisms Behind Tissue Damage in the Diseased Gingiva.
3/2018	Proteolytic effects of gingipains on trefoil factor family peptides.
1/2017	Inactive Gingipains from P. gingivalis Selectively Skews T Cells toward a Th17 Phenotype in an IL-6 Dependent Manner.
3/2016	Antibodies to Porphyromonas gingivalis Indicate Interaction Between Oral Infection, Smoking, and Risk Genes in Rheumatoid Arthritis Etiology.
1/2016	Gingipains of Porphyromonas gingivalis Affect the Stability and Function of Serine Protease Inhibitor of Kazal-type 6 (SPINK6), a Tissue Inhibitor of Human Kallikreins.
11/2014	Structure and mechanism of cysteine peptidase gingipain K (Kgp), a major virulence factor of Porphyromonas gingivalis in periodontitis.
4/2013	Cleavage of extracellular matrix in periodontitis: gingipains differentially affect cell adhesion activities of fibronectin and tenascin-C.

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Barbara Potempa Research Topics

Disease

7	Periodontitis 01/2022 - 04/2013
3	Chronic Periodontitis 03/2018 - 11/2014
3	Rheumatoid Arthritis 11/2016 - 01/2016
2	Bone Resorption 01/2022 - 01/2017
2	Inflammation (Inflammations) 04/2020 - 01/2017
2	Infections 01/2020 - 03/2016
2	Periodontal Diseases (Periodontal Disease) 05/2013 - 04/2013
1	Periodontal Pocket (Periodontal Pockets) 01/2022
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2019
1	Bacterial Infections (Bacterial Infection) 01/2017
1	Neoplasms (Cancer) 11/2015
1	Arthritis (Polyarthritis) 11/2014
1	Dysbiosis 11/2014

Drug/Important Bio-Agent (IBA)

8	Gingipain Cysteine EndopeptidasesIBA 01/2022 - 04/2013
4	Virulence Factors (Pathogenicity Factors)IBA 01/2022 - 11/2014
3	Cysteine Proteases (Cysteine Protease)IBA 01/2022 - 01/2016
3	Peptide Hydrolases (Proteases)FDA Link 01/2020 - 05/2013
3	AntibodiesIBA 11/2016 - 01/2016
2	Cysteine (L-Cysteine)FDA Link 01/2022 - 11/2014
2	EnzymesIBA 01/2019 - 03/2016
2	EpitopesIBA 03/2016 - 11/2015
2	Anti-Citrullinated Protein AntibodiesIBA 03/2016 - 01/2016
1	Phosphotransferases (Kinase)IBA 01/2022
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 01/2022
1	Oxygen (Dioxygen)IBA 01/2022
1	Peptides (Polypeptides)IBA 04/2020
1	KininsIBA 04/2020
1	Proteins (Proteins, Gene)FDA Link 01/2020
1	Telomerase (Telomerase Reverse Transcriptase)IBA 01/2020
1	Membrane Proteins (Integral Membrane Proteins)IBA 01/2020
1	Tiopronin (Thiola)FDA Link 01/2019
1	Trefoil FactorsIBA 03/2018
1	Interleukin-6 (Interleukin 6)IBA 01/2017
1	acetyl 4-aminosalicylic acidIBA 03/2016
1	Immunoglobulin G (IgG)IBA 03/2016
1	ImmunosorbentsIBA 03/2016
1	HLA-DRB1 Chains (HLA DRB1)IBA 03/2016
1	AgglutininsIBA 11/2015
1	LectinsIBA 11/2015
1	AcetylgalactosamineIBA 11/2015
1	Toll-Like Receptors (Toll-Like Receptor)IBA 11/2014
1	TenascinIBA 04/2013
1	Biological ProductsIBA 04/2013
1	Fibronectins (Fibronectin)IBA 04/2013